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Why You're Stiff in the Morning: Your Body Suppresses Inflammation When You Sleep at Night

(Federation of American Societies for Experimental Biology) New research … describes a protein created by the body's "biological clock" that actively represses inflammatory pathways within the affected limbs during the night. This protein, called CRYPTOCHROME, has proven anti-inflammatory effects in cultured cells and presents new opportunities for the development of drugs that may be used to treat inflammatory diseases and conditions, such as arthritis.
"By understanding how the biological clock regulates inflammation, we can begin to develop new treatments, which might exploit this knowledge," said Julie Gibbs, Ph.D., a researcher involved in the work and arthritis research UK career development fellow at the Centre for Endocrinology and Diabetes at the Institute of Human Development at the University of Manchester, United Kingdom. "Furthermore, by adapting the time of day at which current drug therapies are administered, we may be able to make them more effective."
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