(WCVB Boston) Are researchers close to redefining how Alzheimer's disease causes brain cells to fail?
A new drug known as T3D-959 treats the disease as though it's actually "diabetes of the brain" -- and many medical experts are encouraged by its results so far in drug studies.
"It's a unique molecule, a unique investigational drug which is designed to hit the very earliest stages before even the plaques and tangles develop and the memory problems develop in these patients," explained Dr. Warren Strittmatter, chief scientific officer at T3D Therapeutics and the former chief of neurology at Duke University Medical Center.
Strittmatter said the brain is dependent on glucose as an energy source. A reduction in glucose metabolism in the brain is one of the hallmarks of Alzheimer's disease.
"Cells of the brain, like we see cells in the body of diabetes, are not able to use glucose as much," said Dr. Marc Agronin, a geriatric psychiatrist serving as the drug's principal investigator. "The goal of the medication like T3D-959 would be to enhance brain cells' ability to use this fuel to enhance metabolism."[Click the title, above, to post a comment.]