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Kidney Stone Mystery Solved: Why Some People Are More Prone to Develop Kidney Stones

(Science Daily) Kidney stones strike an estimated 1 million Americans each year, and those who have experienced the excruciating pain say it is among the worst known to man (or woman)…
Most kidney stones form when the urine becomes too concentrated, allowing minerals like calcium to crystallize and stick together. Diet plays a role in the condition -- not drinking enough water or eating too much salt (which binds to calcium) also increases the risk of stones.
But genes are partly to blame. A common genetic variation in a gene called claudin-14 recently has been linked to a substantial increase in risk -- roughly 65 percent -- of getting kidney stones. In [a] new study, the researchers have shown how alterations in the gene's activity influence the development of stones…
[Says senior author Jianghui Hou, PhD,] "Now that we understand the physiology of the condition, we can start to think about better treatments or even ways to prevent stones from developing in the first place."
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