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Potential Alzheimer's Disease Drug Slows Damage and Symptoms in Animal Model

(Science Daily) A compound that previously progressed to Phase II clinical trials for cancer treatment slows neurological damage and improves brain function in an animal model of Alzheimer's disease, according to a new study. The study … shows that the compound epothilone D (EpoD) is effective in preventing further neurological damage and improving cognitive performance in a mouse model of Alzheimer's disease (AD). The results establish how the drug might be used in early-stage AD patients…
Unlike many microtubule-stabilizing compounds, EpoD readily enters the brain, where it appears to persist for a much longer time than in the blood. This feature may explain why low doses were both effective and safe in the mouse model of AD.
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