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Insulin Action in the Brain Can Lead to Obesity

(Science Daily) Fat-rich food makes you fat. Behind this simple equation lie complex signalling pathways, through which the neurotransmitters in the brain control the body's energy balance. Scientists … have clarified an important step in this complex control circuit. They have succeeded in showing how the hormone insulin acts in the part of the brain known as the ventromedial hypothalamus.
The consumption of high-fat food causes more insulin to be released by the pancreas. This triggers a signalling cascade in special nerve cells in the brain… Over the course of several intermediary steps, the insulin inhibits the transmission of nerve impulses in such a way that the feeling of satiety is suppressed and energy expenditure reduced. This promotes overweight and obesity.
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